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Studies

Selection of studies

Studies (selection)

  • FAM-Study (NCT00393692)
    Multicenter, natural history study funded by the German Research Council (DFG), started in 2000, ongoing
  • Fenretinide-Study (NCT00429936)
    Interventional study sponsored by Sirion Therapeutics, Inc. GRADE involved in screening visits in 2006-2007
  • GAP-Study (NCT00599846)
    Natural history study sponsored by Alcon Research, Inc. GRADE served as subcontractor to the DUKE OCT-Reading Center, grading limited to cSLO imaging, including FAF; 2008-2010
  • GATE-Study (NCT00890097)
    Treatment study sponsored by Alcon Research, Inc. GRADE served as subcontractor to the DUKE OCT-Reading Center, grading limited to cSLO imaging, including FAF; 2009-2012
  • Mahalo-Study (NCT01229215)
    Treatment study sponsored by Genentech, Inc. GRADE serves as subcontractor to DIRC-Reading Center, qualitative grading of cSLO images, including FAF; 2011-2013
  • Comrade-B/Comrade-C and Comarde Extension Studies (NCT01396057 and NCT01396083)
    Treatment study sponsored by Novartis Deutschland GmbH in branch and central venous occlusion. GRADE serves as central reading center with color fundus photography, fluorescein angiography and optical coherence tomography as imaging modalities; 2011 -2015
  • HELP-Study
    Observational study in pathological myopia, sponsored by Novartis Pharma Germany in high-risk patients with myopia; 2013 - ongoing
  • OCEAN/ORCA- Study
    Observational study, sponsored by Novartis Pharma Germany in patients with exudative age-related macular degeneration, diabetic macular edema and retinal vein occlusions under Ranibizumab treatment. Independent reading of imaging data, particularly SD-OCT imaging in addition to local investigators. GRADE is head reading center, collaborating with CIRCL and MM3; 2012 - 2017
  • Vivid East Study
    Treatment study in diabetic macular edema with Aflibercept, sponsored by Bayer. GRADE serves as specialist reading center, validating processed data
  • Beacon- Study (NCT02087085)
    Phase2b- study sponsored by Allergan, Inc. GRADE serves as the central Reading Center, also involving scotopic microperimetry and quantitative FAF imaging (qAF), 2013-2018
  • Chroma/Spectri/Proxima/GX29633- Studies (NCT02247479, NCT02247531 ...)
    Treatment (Phase 2 and 3) and natural history studies, sponsored by Roche/Genentech, Inc. - part of a large program in geographic atrophy; GRADE serves as specialist reading center, qualitative cSLO grading, 2014-2018
  • Safari- Study (NCT02161575)
    Phase4-study in neovascular AMD, sponsored by Novartis, GRADE serves as the central reading center, 2014 - 2018
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